Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

8.5K
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
8.5K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.0K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.0K
Neurulation01:30

Neurulation

47.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Symmetric Dimethylarginine for Risk Stratification of Cardioembolic Stroke.

Translational stroke research·2026
Same author

Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes.

Nature genetics·2026
Same author

Septin multimer autoantibodies in severe motor neuropathy mimicking lower motor neuron disease.

Brain : a journal of neurology·2026
Same author

Corrigendum to "Erythropoietin targets parvalbumin-positive inhibitory neurons and microglia to promote plasticity in the thalamic reticular nucleus" [Neuropharmacology 297 (2026) 111025].

Neuropharmacology·2026
Same author

Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport.

bioRxiv : the preprint server for biology·2026
Same author

Erythropoietin targets parvalbumin-positive inhibitory neurons and microglia to promote plasticity in the thalamic reticular nucleus.

Neuropharmacology·2026

Related Experiment Video

Updated: Mar 17, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K

Cortical network dysfunction caused by a subtle defect of myelination.

Giulia Poggi1, Susann Boretius2,3, Wiebke Möbius4

  • 1Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen.

Glia
|July 30, 2016
PubMed
Summary

Subtle white matter abnormalities in Mbp(+/-) mice led to reduced prefrontal cortex myelination. This primary myelin defect caused sensorimotor gating deficits and catatonia, suggesting a cause for neuropsychiatric conditions.

Keywords:
Cnp mutantMRIcatatoniaelectron microscopymyelin basic protein (Mbp) mutantprepulse inhibition

More Related Videos

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
08:07

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin

Published on: March 24, 2023

2.3K
Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

12.0K

Related Experiment Videos

Last Updated: Mar 17, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K
Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
08:07

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin

Published on: March 24, 2023

2.3K
Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
09:41

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures

Published on: March 20, 2019

12.0K

Area of Science:

  • Neuroscience
  • Neurobiology
  • Genetics

Background:

  • White matter abnormalities are observed in mentally ill individuals.
  • The role of reduced white matter and myelin in disease phenotypes is unclear.
  • Mbp heterozygous mice, a model related to neurological mutants, were studied.

Purpose of the Study:

  • To investigate if subtle white matter abnormalities in Mbp(+/-) mice contribute to disease-relevant phenotypes.
  • To explore the consequences of reduced myelin in the central nervous system (CNS).

Main Methods:

  • Comprehensive phenotyping of Mbp(+/-) and Mbp(+/+) mice from 2 to 20 months of age.
  • Utilized behavioral/cognitive testing, MRI, 1H-MR spectroscopy, electron microscopy, and molecular techniques.
  • Analyzed myelination, inflammation, and behavioral functions.

Main Results:

  • Significantly reduced Mbp-dependent myelination in the prefrontal cortex of Mbp(+/-) mice.
  • Mild, progressive hypomyelination of the prefrontal corpus callosum and low-grade inflammation observed.
  • Mbp(+/-) mice showed preserved general behavior but deficits in sensorimotor gating (reduced prepulse inhibition) and late-onset catatonia.

Conclusions:

  • Subtle, primary abnormalities in CNS myelin can cause persistent cortical network dysfunction.
  • Catatonia and other features observed in Mbp(+/-) mice are typical of neuropsychiatric conditions.
  • This study links primary myelin defects to neurological and psychiatric phenotypes.