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Updated: Mar 17, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
[The change of vaginal lactobacillus in patients with high-risk human papillomavirus infection]
1Department of Obstetrics and Gynecology, Beijing Hospital, Beijing 100730, China.
Objective:
To study the distribution characteristics of lactobacillus in the vaginal mucosa of patients with HPV infection.
Methods:
The planting density of lactobacillus in vaginal secretions of 95 cases with HPV16/18 infection and 90 cases of normal women of childbearing age were observed by oil microscope. And the strains of vaginal lactobacilli in two groups were analyzed using species-specific polymerase chain reaction (Species-specific PCR) and the distribution of vaginal lactobacilli in patients with HPV16/18 infection were investigated.
Results:
In HPV16/18 infective groups, the planting density of lactobacillus in the vaginal mucosa was 104 (68-186)/HP. It was significantly lower than that of the normal group (234 (161-326)/HP, P<0.05). Compared with the normal group, the positive rates of lactobacillus iners, lactobacillus crispatus, and lactobacillus gasseri were significantly lower in HPV16/18 infection group (P<0.05).
Conclusion:
The HPV16/18 infection is associated with the decreased number of lactobacillus and the imbalance of vaginal flora; Lactobacillus iners, lactobacillus crispatus, and lactobacillus gasseri may play a key role in maintaining the vaginal micro ecological environment.
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