Related Experiment Video

Updated: Mar 17, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

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Splice Variants of Androgen Receptor and Prostate Cancer

Orazio Caffo1, Francesca Maines1, Antonello Veccia1

  • 1Medical Oncology Department, Santa Chiara Hospital , Trento, Italy.

Oncology Reviews
|July 30, 2016
PubMed

Insights

Androgen receptor splice variants are key to understanding resistance in metastatic castration-resistant prostate cancer (mCRPC) to new hormonal drugs. Their role in chemotherapy resistance is less significant, suggesting biomarker potential for treatment decisions.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Metastatic castration-resistant prostate cancer (mCRPC) has seen new drug approvals, including hormonal agents and chemotherapeutics.
  • Patient response varies, with primary and secondary resistance limiting treatment efficacy.
  • Androgen receptor splice variants (AR-Vs) are implicated in resistance mechanisms.

Purpose of the Study:

  • To review the role of AR-Vs in prostate cancer biology.
  • To evaluate the impact of AR-Vs on resistance to novel mCRPC therapies.
  • To explore the potential of AR-Vs as biomarkers for guiding therapeutic decisions.

Main Methods:

  • Literature review of published data.
  • Analysis of studies investigating AR-Vs in prostate cancer.
  • Synthesis of evidence on AR-V involvement in drug resistance.

Main Results:

  • AR-Vs are strongly associated with primary and secondary resistance to new hormonal drugs in mCRPC.
  • The effect of AR-Vs on the efficacy of chemotherapeutic agents appears to be partial.
  • AR-Vs are crucial in understanding treatment failure for hormonal therapies.

Conclusions:

  • Androgen receptor splice variants play a significant role in resistance to hormonal therapies for mCRPC.
  • AR-Vs have a limited role in resistance to chemotherapy in mCRPC.
  • AR-Vs show potential as predictive biomarkers for selecting appropriate treatments in mCRPC.
Keywords:
Prostate cancerabirateronecabazitaxelenzalutamidesplice variants

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