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Related Concept Videos

Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Related Experiment Video

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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Antigen-based immunotherapy for autoimmune disease: current status.

Darren Lowell Hirsch1, Punita Ponda1

  • 1Division of Allergy and Immunology, North Shore-Long Island Jewish Health System/Hofstra North Shore-LIJ School of Medicine, New Hyde Park, NY, USA.

Immunotargets and Therapy
|July 30, 2016
PubMed
Summary
This summary is machine-generated.

Antigen-specific immunotherapy offers a promising approach to treating autoimmune diseases by promoting immune tolerance. This review explores current research and clinical trials investigating antigen-based therapies for these chronic conditions.

Keywords:
antigenautoimmune diseasediabetesimmunotherapymultiple sclerosisrheumatoid arthritis

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Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Therapeutics

Background:

  • Autoimmune diseases are chronic, potentially life-threatening conditions impacting quality of life.
  • Current treatments offer benefits but can cause significant side effects.
  • There is a need for targeted therapies with limited systemic effects.

Purpose of the Study:

  • To review the current status of antigen-specific immunotherapy for autoimmune diseases.
  • To examine studies and clinical trials in human and animal models.
  • To highlight the potential of antigen-based therapies in promoting immune tolerance.

Main Methods:

  • Review of existing scientific literature and clinical trial data.
  • Analysis of studies employing antigen-based immunotherapy strategies.
  • Focus on research involving both human and animal subjects.

Main Results:

  • Antigen-specific immunotherapy aims to induce immune deviation and tolerance.
  • This approach targets disease-associated antigens, potentially reducing side effects.
  • Evidence from studies and trials supports its therapeutic potential.

Conclusions:

  • Antigen-based immunotherapy represents a promising strategy for autoimmune disease management.
  • The goal is to achieve targeted immune modulation and enhance patient outcomes.
  • Further research and clinical trials are crucial for advancing this therapeutic modality.