Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K
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Updated: Mar 17, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Chao Liu1, Song Ang1, Xiao-Jun Huang1
1Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and ‡JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University , Guangzhou 510632, People's Republic of China.
Abstract:
Five sesquiterpene-based meroterpenoids with three kinds of new skeletons [1, 2, 3, (+)-4, and (-)-4] were isolated from the leaves of Myrtus communis. Compound 1 featured a new carbon skeleton with an unprecedented octahydrospiro[bicyclo[7.2.0]undecane-2,2'-chromene] tetracyclic ring system, which possessed two preferred conformations detected by variable-temperature NMR spectroscopy experiments. In addition, the structure of reported myrtucommulone K was revised to be compound 3. The plausible biosynthetic pathways of these meroterpenoids and their cytotoxicities are discussed.
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