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Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2

A L Solebo1,2,3,4, I Russell-Eggitt2,4, P Cumberland1,4

  • 1Lifecourse Epidemiology and Biostatistics Section, Population, Policy and Practice Programme, University College London Institute of Child Health, London, UK.

Eye (London, England)
|July 30, 2016
PubMed

Insights

Persistent fetal vasculature (PFV) affects 24% of children undergoing cataract surgery in their first two years. Outcomes for PFV patients are similar to general cataract surgery cases.

Area of Science:

  • Ophthalmology
  • Pediatric Surgery
  • Genetics

Background:

  • Persistent fetal vasculature (PFV) is a congenital eye condition.
  • Understanding PFV's prevalence and impact in pediatric cataract surgery is crucial.

Purpose of the Study:

  • To determine the frequency and characteristics of PFV in children.
  • To evaluate treatment outcomes for PFV in pediatric cataract surgery patients.

Main Methods:

  • Observational, population-based cohort study.
  • Utilized active surveillance and standardized data collection via the British Isles Congenital Cataract Interest Group (BCCIG).

Main Results:

  • PFV identified in 24% of 246 children undergoing cataract surgery within the first two years of life.
  • Higher prevalence of anterior segment vascular remnants in bilateral PFV (75%) compared to unilateral (11%).
  • One-year post-surgery visual outcomes were 20% (bilateral PFV) and 24% (unilateral PFV); glaucoma prevalence was 9% (bilateral) and 4% (unilateral).

Conclusions:

  • PFV is more prevalent than previously thought in pediatric cataract cases.
  • Outcomes for children with PFV are comparable to those with congenital and infantile cataracts overall.

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