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Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
Published on: April 8, 2016
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Immunohistochemistry as a Practical Tool in Molecular Pathology.
1From the Department of Pathology, Vancouver General Hospital, Vancouver, Canada.
Archives of Pathology & Laboratory Medicine
|July 30, 2016
Summary
Immunohistochemistry (IHC) is a vital tool in molecular diagnostics, aiding pathologists in tumor subtyping, hereditary cancer screening, and predicting treatment response for personalized medicine.
Area of Science:
- Pathology
- Molecular Diagnostics
- Oncology
Background:
- Molecular genetics is increasingly crucial in patient care and pathology.
- Immunohistochemistry (IHC) is a routinely used, practical diagnostic tool for pathologists.
Purpose of the Study:
- To showcase specific applications of IHC in molecular diagnostics.
- To illustrate how IHC enhances patient care and molecular testing.
Main Methods:
- Review of select literature on IHC applications.
- Focus on tumor subtyping, hereditary cancer screening, and treatment-response prediction.
Main Results:
- IHC facilitates accurate tumor subtyping.
- IHC aids in screening for hereditary cancer syndromes.
- IHC assists in predicting patient response to therapies.
Conclusions:
- IHC remains essential in the era of personalized medicine.
- IHC complements and enhances other advanced molecular techniques.
- IHC empowers anatomic pathologists to optimize patient management.
