Specific chromosome changes and nonoccupational exposure to potentially carcinogenic agents in acute leukemia in...

Cytogenetic studies were performed on 44 Chinese patients with acute leukemia. A high percentage of patients (37.5%) with t(8;21), t(15;17) or 17q- (in poorly banded preparations), and abnormalities involving 11q23 were noted in 32 unselected patients with ANLL. A similar high percentage was previously reported in Japan and in South Africa but not in western countries. Data on casual or other non-occupational exposure to potentially carcinogenic agents were obtained by interview with the patients at their first presentation. Most patients with these three major chromosomal changes had a history of exposure, whereas most other patients did not (p = 0.01). Patients with ANLL-M3 were more often exposed than were the other patients (4/6 vs 8/38, p = 0.03). The only common exposure was to organophosphate insecticides. Twenty seven cases of therapy-related leukemia were collected from the Chinese medical literature, and 12 out of 22 (55%) cases in which subtypes were specified were ANLL-M3. This was significantly higher than the percentage of M3 in de novo ANLL in China and also higher than that of therapy-related leukemia from western countries. Two patients had siblings who died of leukemia at a similar age. The two patients showed inv(16) and del(6q) respectively.