Related Experiment Video

Updated: Mar 17, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Functional mitral regurgitation: predictor for atrial substrate remodeling and poor ablation outcome in paroxysmal

Yu Qiao1, Lingmin Wu, Bingbo Hou

  • 1State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Medicine
|July 30, 2016
PubMed

Insights

Functional mitral regurgitation (FMR) is linked to atrial remodeling in patients with paroxysmal atrial fibrillation (PAF). FMR independently predicts both atrial substrate changes and a higher risk of AF recurrence after ablation.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Surgery

Background:

  • Functional mitral regurgitation (FMR) is frequently observed in patients with atrial fibrillation (AF).
  • The relationship between FMR, atrial substrate remodeling, and ablation outcomes in paroxysmal AF (PAF) requires further investigation.

Purpose of the Study:

  • To investigate the association between FMR and atrial substrate remodeling.
  • To evaluate the impact of FMR on the success of catheter ablation for PAF.

Main Methods:

  • Retrospective analysis of 132 symptomatic PAF patients undergoing initial ablation.
  • Functional mitral regurgitation defined by regurgitation jet area to left atrium area ratio ≥ 0.1.
  • Left atrial voltage mapping to assess low voltage zones (LVZs); FMR independently predicted LVZs.
  • Follow-up for AF recurrence over a mean of 22.9 months.

Main Results:

  • 40 patients (29.6%) had FMR, were older, and had larger left atrial diameters.
  • Patients with FMR showed significantly more left atrial low voltage zones (64.9% vs 22.1%).
  • FMR independently predicted the presence of LVZs (OR 7.286).
  • AF recurrence rate was higher in the FMR cohort (60.0% vs 19.5%) and FMR was an independent predictor of recurrence (HR 2.291).

Conclusions:

  • Functional mitral regurgitation is strongly associated with atrial substrate remodeling in PAF patients.
  • FMR is an independent predictor of AF recurrence following catheter ablation.
  • Patients with FMR have a substantially higher risk of AF recurrence post-ablation.

More Related Videos

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

4.5K
Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

1.5K

Related Concept Videos

Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
718
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
863
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
500
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
387
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
847
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
791