Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

3.3K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.3K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

4.3K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the Effects of UVC Exposure at the Limbus.

Cells·2026
Same author

Diagnostic utility of inflammation-associated clinical signs in detecting MMP-9 expression in dry eye disease: A cross-sectional conjunctival impression cytology and droplet digital PCR study.

Contact lens & anterior eye : the journal of the British Contact Lens Association·2026
Same author

Optimising slit-lamp biomicroscope fluorescein imaging filters.

Contact lens & anterior eye : the journal of the British Contact Lens Association·2026
Same author

Corrigendum to "TFOS DEWS III: Digest" Am J Ophthalmol. 2025; 279:451-553.

American journal of ophthalmology·2026
Same author

Validation and Comparative Analysis of a Contemporary Non-Contact Corneal Aesthesiometer.

Journal of clinical medicine·2026
Same author

Pharmacological, Natural and Emerging Therapies for Meibomian Gland Dysfunction: A Review.

Drugs·2026

Related Experiment Video

Updated: Mar 17, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

3.0K

Ocular surface microbiome in meibomian gland dysfunction.

Grant A Watters1,2, Philip R Turnbull2, Simon Swift3

  • 1Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand.

Clinical & Experimental Ophthalmology
|July 31, 2016
PubMed
Summary

The ocular microbiome in meibomian gland dysfunction (MGD) patients in New Zealand showed minimal variation across MGD severity, anterior blepharitis, or contact lens wear. This suggests a common treatment approach may be effective for MGD patients.

Keywords:
bacteriablepharitisdry eyemeibomian gland dysfunctionmicrobiome

More Related Videos

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
05:00

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

15.8K
Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

858

Related Experiment Videos

Last Updated: Mar 17, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
06:38

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

3.0K
Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction
05:00

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

15.8K
Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

858

Area of Science:

  • Ophthalmology
  • Microbiology
  • Genomics

Background:

  • Meibomian gland dysfunction (MGD) is a common condition affecting the ocular surface.
  • Understanding the ocular microbiome is crucial for managing MGD.
  • Previous studies on the ocular microbiome have shown geographical variations.

Purpose of the Study:

  • To investigate the ocular microbiome in individuals with varying degrees of meibomian gland dysfunction (MGD) in Auckland, New Zealand.
  • To explore the influence of MGD severity, anterior blepharitis, and contact lens wear on the ocular microbiome.

Main Methods:

  • A prospective, cross-sectional study involving 157 participants classified by MGD severity.
  • Lid margin swabs were collected before and after gland expression for bacterial culture.
  • Aerobic and anaerobic bacteria were identified using conventional microbiological techniques.

Main Results:

  • Ocular microbiome composition showed similarity across different MGD severity levels.
  • Gland expression did not significantly alter the microbiome profile.
  • Anterior blepharitis and contact lens wear did not independently predict microbiome composition, though sterile cultures were more frequent in contact lens wearers.
  • Staphylococcus aureus incidence was higher than expected, while coagulase-negative Staphylococcus, Corynebacterium, and streptococci were less common.

Conclusions:

  • The ocular microbiome in this New Zealand cohort exhibited modest differences compared to other studies, potentially reflecting climatic variations.
  • The consistent microbiome profile across MGD severity, anterior blepharitis, and contact lens wear suggests a potential for standardized treatment strategies.
  • Further research into the specific bacterial species and their roles in MGD pathogenesis is warranted.