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Updated: Mar 17, 2026
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
Correlation of cognitive and masticatory function in Alzheimer's disease
Camila Heitor Campos1, Giselle Rodrigues Ribeiro1, José Luiz Riani Costa2
1Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Avenida Limeira, no. 901, Bairro Areião, Piracicaba, SP, CEP: 13414-903, Brazil.
Objectives:
This study investigated chewing function in elderly individuals with Alzheimer's disease (AD) and correlated chewing function with cognitive status.
Materials And Methods:
Sixteen elderly individuals with mild AD (mean age 76.7 ± 6.3 years; 8 men, 8 women) and 16 age and gender-matched healthy controls (mean age 75.23 ± 4.4 years; 8 men, 8 women) were included in this study. All volunteers wore removable prostheses: 11 were totally edentulous and five were partially edentulous in each group. Chewing function was evaluated via masticatory performance (MP) using Optocal chewable test material and a sieve fractionation method. Cognitive functioning was assessed by the Mini Mental State Exam (MMSE), administered by a trained examiner. Data were analyzed by non-paired t test and Pearson's correlation with α = 0.05.
Results:
Compared to controls, mild AD patients had decreased MP (P < 0.01) and MMSE (P = 0.01). MP showed a moderate negative correlation with MMSE (r = -0.69).
Conclusions:
Mild AD was associated with impaired chewing function.
Clinical Relevance:
Knowledge that mild AD has an impact on chewing is important for dental professionals in decision-making related to prosthetics and general dental treatment.
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