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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Spontaneous resolution of left bundle branch block and biventricular stimulation lead to reverse remodeling in

Mariëlle Kloosterman1, Michiel Rienstra1, Isabelle C Van Gelder1

  • 1Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Journal of Electrocardiology
|July 31, 2016
PubMed

Insights

Left bundle branch block (LBBB) can cause heart muscle disease and worsen heart function. Reversing LBBB through heart failure medication or cardiac resynchronization therapy can normalize heart function and improve the condition.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Left bundle branch block (LBBB) is often associated with structural heart disease.
  • The causal relationship between LBBB and left ventricular (LV) dysfunction is complex and often diagnosed together.

Observation:

  • A patient presented with LBBB and impaired LV function.
  • The patient received heart failure medication, leading to LBBB reversal and LV function normalization.
  • Years later, a cardiac resynchronization device implantation also resulted in LBBB reversal and improved LV function.

Findings:

  • LBBB can be a direct cause of non-ischemic cardiomyopathy.
  • Resolution of LBBB can induce reverse remodeling in patients with dyssynchronopathy.

Implications:

  • LBBB may be a modifiable cause of heart failure.
  • Therapeutic strategies targeting LBBB could improve LV function and reverse cardiac remodeling.

Keywords:
Cardiac resynchronization therapyDyssynchronopathyLeft bundle branch blockNon-ischemic cardiomyopathyReverse remodeling

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