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Reduced serum concentrations of brain-derived neurotrophic factor (BDNF) in transsexual Brazilian men
Anna Martha Vaitses Fontanari1, Angelo Brandelli Costa2, Bianca Aguiar1
1Department of Psychiatry/Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Abstract:
Serum BDNF levels are significantly decreased in transsexual Brazilian women when compared to cis-sexual men. Since transsexual men are also exposed to chronic social stress and have a high prevalence of associated psychopathologies, it is plausible to inquire if BDNF serum levels are altered in transsexual men as well. Therefore, our objective was to evaluate differences in BDNF serum level of transsexual men when compared to cis-sexual men and women. Our sample comprises 27 transsexual men, 31 cis-sexual women and 30 cis-sexual men recruited between 2011 and 2015. We observed that BDNF serum concentration is decreased in transsexual men comparing to cis-sexual men and women. Cross-sex hormone treatment, chronic social stress or long-term gender dysphoria (GD) could explain the variation found in BDNF serum levels.
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