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Updated: Mar 17, 2026
Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae
Published on: March 25, 2015
One-pot fabrication of silver nanocrystals using Nicandra physalodes: A novel route for mosquito vector control with
Marimuthu Govindarajan1, Hanem F Khater2, Chellasamy Panneerselvam3
1Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India.
Abstract:
Mosquitoes (Diptera: Culicidae) as vectors for important diseases and parasites causing millions of deaths every year. The use of synthetic pesticides against Culicidae leads to resistance and environmental concerns. Therefore, eco-friendly control tools are a priority. In this research, Nicandra physalodes-mediated synthesis of silver nanoparticles (Ag NPs) was conducted, in order to control larval populations of three important mosquito vectors, Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Biofabricated Ag NPs were characterized using UV-vis spectrophotometry, XRD, FTIR spectroscopy, SEM, and TEM analyses. Ag NPs were highly toxic against the three mosquito vectors. Maximum efficacy was detected against A. stephensi (LC50=12.39μg/mL), followed by Ae. aegypti (LC50=13.61μg/mL) and Cx. quinquefasciatus (LC50=14.79μg/mL). Interestingly, Ag NPs were safer for the non-target aquatic organism Diplonychus indicus sharing the same aquatic habitats of mosquito larvae. LC50 and LC90 values were 1032.81 and 19,076.59μg/mL, respectively. Overall, our results highlight that N. physalodes-fabricated Ag NPs are a promising for development of eco-friendly larvicides against mosquito vectors, with negligible toxicity against non-target aquatic water bugs.
