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Acute Methiopropamine Intoxication After "Synthacaine" Consumption

A Daveluy1, N Castaing2, H Cherifi3

  • 1Service de pharmacologie médicale, centre d'addictovigilance, CHU Bordeaux.

Journal of Analytical Toxicology
|July 31, 2016
PubMed

Insights

Methiopropamine (MPA), a synthetic stimulant, caused acute toxicity in a patient using "synthacaine." This case highlights the need for advanced toxicological analysis to identify new psychoactive substances.

Area of Science:

  • Clinical Toxicology
  • Pharmacology
  • Forensic Science

Background:

  • Methiopropamine (MPA), a synthetic amphetamine analog, has been increasingly detected in Europe since 2011.
  • Limited data exists regarding the acute toxicity profile of MPA.

Observation:

  • A 30-year-old male presented with acute confusion, paranoia, and hallucinations after consuming "synthacaine."
  • Clinical examination revealed altered mental status and incoherent speech.

Findings:

  • Toxicological analysis using LC-MS-MS confirmed the presence of MPA in the patient's plasma.
  • MPA concentration was measured at 14 ng/mL, 13 hours post-admission.

Implications:

  • This case confirms the acute toxicity of methiopropamine.
  • Highlights the critical role of sophisticated toxicological screening in identifying novel psychoactive substances.
  • Underscores the potential dangers associated with designer drugs like synthacaine.

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