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Updated: Jul 16, 2026
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Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
Published on: November 21, 2012
Acute Methiopropamine Intoxication After "Synthacaine" Consumption.
A Daveluy1, N Castaing2, H Cherifi3
1Service de pharmacologie médicale, centre d'addictovigilance, CHU Bordeaux.
Journal of Analytical Toxicology
|July 31, 2016
Summary
Methiopropamine (MPA), a synthetic stimulant, caused acute toxicity in a patient using "synthacaine." This case highlights the need for advanced toxicological analysis to identify new psychoactive substances.
Area of Science:
- Clinical Toxicology
- Pharmacology
- Forensic Science
Background:
- Methiopropamine (MPA), a synthetic amphetamine analog, has been increasingly detected in Europe since 2011.
- Limited data exists regarding the acute toxicity profile of MPA.
Observation:
- A 30-year-old male presented with acute confusion, paranoia, and hallucinations after consuming "synthacaine."
- Clinical examination revealed altered mental status and incoherent speech.
Findings:
- Toxicological analysis using LC-MS-MS confirmed the presence of MPA in the patient's plasma.
- MPA concentration was measured at 14 ng/mL, 13 hours post-admission.
Implications:
- This case confirms the acute toxicity of methiopropamine.
- Highlights the critical role of sophisticated toxicological screening in identifying novel psychoactive substances.
- Underscores the potential dangers associated with designer drugs like synthacaine.
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