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Formula Feeding Is Independently Associated With Acute Kidney Injury in Very Low Birth Weight Infants

Gemma Ginovart1, Ignasi Gich2, Sergio Verd3

  • 11 Neonatal Unit, Department of Paediatrics, Hospital de la Santa Creu i Sant Pau, Barcelona Free University (UAB), Barcelona, Spain.

Journal of Human Lactation : Official Journal of International Lactation Consultant Association
|July 31, 2016
PubMed

Insights

Human milk feeding significantly reduces the risk of acute kidney injury in very low birth weight infants compared to formula feeding. This finding suggests formula feeding may be an avoidable risk factor for neonatal kidney problems.

Area of Science:

  • Neonatology
  • Pediatric Nephrology
  • Infant Nutrition

Background:

  • Neonatal acute kidney injury lacks effective prevention strategies.
  • Breastfed infants have lower excretory kidney demands due to nutrient intake aligning with requirements.

Purpose of the Study:

  • To investigate if feeding type influences acute kidney injury risk in very low birth weight infants.

Main Methods:

  • A pre-post cohort study enrolled 186 very low birth weight infants.
  • Infants were categorized into human milk-fed (114) or formula-fed (72) groups.
  • Biological markers for acute kidney injury were monitored from birth to discharge.

Main Results:

  • Human milk feeding showed an 80% reduction in acute kidney injury odds (OR=0.2) versus formula feeding.
  • Formula feeding was independently linked to acute kidney injury after controlling for confounders.

Conclusions:

  • Neonatal acute kidney injury at this institution is often linked to formula feeding.
  • Formula feeding may be an avoidable factor contributing to neonatal kidney injury.
  • Further multicenter studies are required to confirm these findings.
Abstract

Keywords:
acute kidney injurybreastfeedingmilk banknewborn infant

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