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Updated: Mar 17, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Quantitative structure property relationship modeling of excipient properties for prediction of formulation
Vinod L Gaikwad1, Neela M Bhatia2, Sujit A Desai2
1Department of Pharmaceutics, P.E. Society's Modern College of Pharmacy, Nigdi, Pune 411044, Maharashtra, India.
Abstract:
Quantitative structure property relationship (QSPR) is used to relate the excipient descriptors with the formulation properties. A QSPR model is developed by regression analysis of selected descriptors contributing towards the targeted formulation properties. Developed QSPR model is validated by the true external method where it showed good accuracy and precision in predicting the formulation composition as experimental t90% (61.35min) is observed very close to predicted t90% (67.37min). Hence, QSPR approach saves resources by predicting drug release from an unformulated formulation; avoiding repetitive trials in the development of a new formulation and/or optimization of existing one.
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