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Polyphenol-chitosan conjugates: Synthesis, characterization, and applications.

Qiaobin Hu¹, Yangchao Luo¹

¹Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.

Carbohydrate Polymers

|July 31, 2016

Summary

Polyphenol-chitosan conjugates enhance chitosan

Keywords:

Antioxidant activity Chitosan Conjugate Drug delivery Film Polyphenols

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Area of Science:

Biomaterials Science
Polymer Chemistry
Medicinal Chemistry

Background:

Chitosan is a unique, positively charged polysaccharide with valuable properties like biodegradability and biocompatibility.
Poor water solubility limits chitosan's applications in food, medicine, and pharmaceuticals.
Polyphenol conjugation is a strategy to improve chitosan's properties and expand its uses.

Purpose of the Study:

To review polyphenol-chitosan conjugates synthesized using various polyphenols.
To detail synthesis methods for these conjugates.
To discuss the enhanced physicochemical and biological properties and novel applications of these conjugates.

Main Methods:

Review of literature on polyphenol-chitosan conjugate synthesis.
Focus on activated ester-mediated modification, enzyme-mediated strategy, and free radical grafting.
Analysis of physicochemical properties (solubility, stability) and biological activities (antioxidant, antimicrobial, anticancer).

Main Results:

Polyphenol conjugation significantly improves chitosan's water solubility and thermal stability.
Conjugates exhibit enhanced in vitro and in vivo antioxidant, antimicrobial, and anticancer activities.
Novel applications are identified across various fields due to improved properties.

Conclusions:

Polyphenol-chitosan conjugates offer improved characteristics over native chitosan.
These conjugates hold significant promise for diverse applications in food, medicine, and pharmaceuticals.
Further research is needed to address challenges and explore future prospective areas.