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Updated: Mar 17, 2026
A Hepatocellular Cancer Patient-Derived Organoid Xenograft Model to Investigate Impact of Liver Regeneration on Tumor Growth
Published on: February 2, 2024
Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm
Eduardo Scortegagna1, Adib R Karam1, Shirin Sioshansi2
1Radiology Department, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655.
Purpose:
This study aims to evaluate the recurrence pattern of hepatocellular carcinoma (HCC) following liver transplantation.
Materials And Methods:
A total of 54 patients underwent liver transplantation for HCC; 9 patients developed biopsy-proven recurrent HCC (16.6%). The site of HCC recurrence along with other factors was analyzed.
Results:
Seven patients were diagnosed with HCC prior to liver transplantation and 2 patients had incidental HCC in the explanted liver. Two patients had locoregional recurrence, 4 patients had distant metastasis, and 3 patients had synchronous locoregional recurrence and distant metastasis.
Conclusion:
A significant proportion of HCC recurrence following liver transplantation is extrahepatic.
