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Efficacy of Ozurdex implant in recalcitrant diabetic macular edema: a single-center experience

Wei Kiong Ngo1, Colin S Tan2,3

  • 1National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore. wkngo@hotmail.com.

International Ophthalmology
|August 1, 2016
PubMed
Abstract

No abstract available in PubMed .

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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