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Disorders of Iron Metabolism and Anemia in Chronic Kidney Disease

Bhupesh Panwar1, Orlando M Gutiérrez2

  • 1Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.

Seminars in Nephrology
|August 1, 2016
PubMed

Insights

Disordered iron homeostasis causes anemia in chronic kidney disease (CKD) and treatment resistance. New insights reveal iron and mineral metabolism links, impacting CKD anemia management.

Area of Science:

  • Nephrology
  • Hematology
  • Mineral Metabolism

Background:

  • Anemia is a common complication of chronic kidney disease (CKD).
  • Dysregulated iron homeostasis is a key factor in CKD anemia development.
  • Altered iron metabolism contributes to resistance to erythropoiesis-stimulating agents in CKD.

Purpose of the Study:

  • To review the pathophysiology of anemia in CKD related to iron metabolism.
  • To explore recent advances in understanding iron regulation and its alterations in CKD.
  • To examine the interplay between iron homeostasis and bone and mineral metabolism in CKD.

Main Methods:

  • Literature review of recent discoveries in iron biology and CKD.
  • Analysis of hormonal regulation of iron trafficking.
  • Exploration of emerging evidence on iron-mineral metabolism interactions.

Main Results:

  • Dysregulated iron homeostasis is central to CKD anemia.
  • Hormonal regulation of iron trafficking is crucial for understanding CKD anemia.
  • Interactions between iron and mineral metabolism offer new insights into CKD pathophysiology.

Conclusions:

  • Understanding normal iron physiology is essential for managing CKD anemia.
  • Altered iron metabolism in CKD is complex and multifactorial.
  • The connection between iron and mineral metabolism has significant implications for managing CKD anemia and iron status.

Keywords:
Hepcidinanemia of chronic kidney diseasechronic kidney diseasefibroblast growth factor 23iron metabolismvitamin D

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