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Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein

V Thamilarasan¹, N Sengottuvelan², A Sudha³

¹Department of Industrial Chemistry, Alagappa University, Karaikudi 630 003, India.

Journal of Photochemistry and Photobiology. B, Biology

|August 1, 2016

Summary

This study synthesized novel cobalt(III) complexes and investigated their DNA binding and anticancer properties. The complexes showed intercalation and minor groove binding modes, with potential for DNA cleavage and cytotoxicity against breast cancer cells.

Keywords:

Biological activities Cobalt(III) complexes DFT calculation Molecular modeling Sodium azide

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Published on: May 28, 2014

Area of Science:

Coordination Chemistry
Bioinorganic Chemistry
Computational Chemistry

Background:

Cobalt(III) complexes are explored for their diverse biological applications.
Understanding the interaction of metal complexes with DNA is crucial for developing novel therapeutic agents.

Purpose of the Study:

To synthesize and characterize novel cobalt(III) complexes.
To investigate their DNA binding modes, serum albumin interaction, DNA cleavage activity, and cytotoxicity against human breast cancer cells.

Main Methods:

Synthesis and single crystal X-ray diffraction for structural determination.
Density functional theory (DFT) calculations for molecular geometry and orbital properties.
UV-visible absorption, fluorescence, circular dichroism, viscosity measurements, docking studies, gel electrophoresis, and in vitro cytotoxicity assays.

Main Results:

Complexes exhibited distorted octahedral geometry around cobalt(III).
Docking studies revealed intercalation and minor groove binding modes with CT-DNA.
Complexes showed binding affinity to bovine serum albumin (BSA) and promoted pBR322 DNA cleavage via singlet oxygen.
Cytotoxicity was observed against human breast cancer (MCF-7) cells.

Conclusions:

The synthesized cobalt(III) complexes demonstrate promising DNA binding and cleavage activities.
These complexes exhibit potential as anticancer agents against human breast cancer cells.