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Related Experiment Video

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Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
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Depression during the perimenopause: A meta-analysis.

M de Kruif1, A T Spijker2, M L Molendijk3

  • 1PsyQ Depression Department, Women's Mental Health, Lijnbaan 4, 2512 VA The Hague, The Netherlands.

Journal of Affective Disorders
|August 1, 2016
PubMed
Summary
This summary is machine-generated.

Women in perimenopause are more vulnerable to depressive symptoms, with higher severity compared to premenopause. Vasomotor symptoms may also increase depression risk during this menopausal transition.

Keywords:
DepressionMenopauseWoman

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Area of Science:

  • Reproductive endocrinology and mental health.
  • Clinical psychology and psychiatry.

Background:

  • Perimenopausal women are believed to be at higher risk for depression.
  • Existing estimates of depression risk during perimenopause are inconsistent.

Purpose of the Study:

  • To investigate the risk of clinical depression and depressive symptoms during perimenopause compared to other female hormonal stages.
  • To quantify the association between perimenopause and depression using meta-analysis.

Main Methods:

  • A meta-analysis of 11 studies was conducted, including literature from PubMed, Web of Science, and Cochrane Library.
  • Studies were included if perimenopause was defined using Stages of Reproductive Aging Workshop (STRAW) criteria.
  • Outcomes included odds ratios for depression diagnosis and depressive symptoms, and standardized mean differences in depression scores.

Main Results:

  • Perimenopause showed a significantly higher risk of depressive symptoms compared to premenopause (OR=2.0).
  • No significant difference in depression risk was found between perimenopause and postmenopause.
  • Depression symptom severity was higher in perimenopause versus premenopause (Hedges's g=0.44).
  • Perimenopausal women with vasomotor symptoms had a 2.25 times higher odds of depression.

Conclusions:

  • Perimenopause is a vulnerable phase for developing depressive symptoms with increased severity.
  • Vasomotor symptoms during menopausal transition appear positively related to depressive symptoms.