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Updated: Mar 17, 2026

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Published on: August 30, 2018
[Targeting high-risk drugs to optimize clinical pharmacists' intervention]
Anne-Laure Mouterde1, Magali Bourdelin1, Ophélie Maison1
1Service de pharmacie, hôpital Nord-Ouest, plateau d'Ouilly, BP 80436, 69655 Villefranche-sur-Saône cedex, France.
Objectives:
By the Order of 6 April 2011, the pharmacist must validate all the prescriptions containing "high-risk drugs" or those of "patients at risk". To optimize this clinical pharmacy activity, we identified high-risk drugs.
Method:
A list of high-risk drugs has been established using literature, pharmacists' interventions (PI) performed in our hospital and a survey sent to hospital pharmacists. In a prospective study (analysis of 100 prescriptions for each high-risk drug selected), we have identified the most relevant to target.
Results:
We obtained a statistically significant PI rate (P<0.05) for digoxin, oral anticoagulants direct, oral methotrexate and colchicine.
Conclusion:
This method of targeted pharmaceutical validation based on high-risk drugs is relevant to detect patients with high risk of medicine-related illness.
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