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Testosterone and the Prostate: Artifacts and Truths.

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Testosterone replacement therapy (TRT) does not worsen lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Evidence suggests TRT may even improve LUTS by reducing metabolic syndrome and prostatic inflammation.

Keywords:
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Area of Science:

  • Andrology
  • Urology
  • Endocrinology

Background:

  • Concerns exist regarding testosterone replacement therapy (TRT) risks for men with lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH).
  • Metabolic syndrome is linked to exacerbated LUTS, and TRT may positively impact metabolic syndrome components.
  • Prostatic inflammation is associated with worsening LUTS, and TRT may possess anti-inflammatory properties relevant to the prostate.

Purpose of the Study:

  • To evaluate the existing evidence on the relationship between TRT and LUTS/BPH.
  • To determine if TRT poses a risk or offers potential benefits for men experiencing LUTS/BPH.

Main Methods:

  • A review of available data and studies investigating TRT's effects on LUTS/BPH was conducted.
  • Analysis focused on reported changes in LUTS severity and related conditions.

Main Results:

  • No studies demonstrated worsening of LUTS in men undergoing TRT.
  • The majority of data indicated no significant change in LUTS.
  • A subset of studies reported occasional improvement in LUTS following TRT.

Conclusions:

  • Current evidence does not support the notion that TRT exacerbates LUTS in men with BPH.
  • TRT may offer benefits for LUTS by addressing associated metabolic and inflammatory factors.
  • Further research may clarify the role of TRT in managing LUTS/BPH.