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Related Experiment Video

Updated: Mar 17, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Human Prostate Cancer Hallmarks Map.

Dipamoy Datta1, Md Aftabuddin2, Dinesh Kumar Gupta3

  • 1Department of Biotechnology, Siksha Bhavana, Visva-Bharati, Santiniketan 731235, India.

Scientific Reports
|August 2, 2016
PubMed
Summary

This study introduces the Human Prostate Cancer Hallmarks Map (HPCHM), an atlas detailing signaling pathways in prostate cancer. It aids understanding of molecular mechanisms driving tumorigenesis and treatment resistance.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Systems Biology

Background:

  • Prostate cancer is a heterogeneous disease in elder males, characterized by high mortality.
  • Tumorigenesis and progression to metastatic castration-resistant disease are driven by hallmark capabilities and aberrant androgen receptor signaling.
  • These capabilities emerge from deregulation of cellular processes, loss of tumor suppression, and disrupted homeostasis.

Purpose of the Study:

  • To develop an onco-functional atlas of human prostate cancer signaling and events.
  • To provide a systems-level understanding of molecular mechanisms in prostate tumorigenesis.
  • To map key protein components, molecular connectivity, and oncogenic signaling pathways.

Main Methods:

  • Extensive manual curation of published biomedical literature.
  • Development of the Human Prostate Cancer Hallmarks Map (HPCHM).
  • Analysis of molecular architecture at various levels, including signaling pathways and functional connectivity.

Main Results:

  • The HPCHM provides a comprehensive overview of prostate cancer signaling.
  • It details key protein interactions and oncogenic pathway maps.
  • The atlas facilitates understanding of pathway-based functional connectivity.

Conclusions:

  • Concurrent inhibition of multiple hallmark-associated pathways is necessary due to molecular complexity.
  • The HPCHM offers a systems-level perspective on prostate cancer molecular mechanisms.
  • This resource aids in understanding the molecular basis of prostate tumorigenesis and treatment resistance.