Related Experiment Videos
Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice
J Allison1, Y L Zhang, M G Parker
1Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Molecular and Cellular Biology
|May 1, 1989
Abstract:
We investigated the tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein by introducing the C3(1) gene with 4-kilobase (kb) upstream and 2-kb downstream flanking sequences into transgenic mice. There was selective expression in the ventral prostate that was stimulated by testosterone, which indicated that the gene together with 6-kb flanking DNA contains the information required for prostate-specific and testosterone-regulated expression.