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The predictive factors for remission of chronic spontaneous urticaria in childhood: Outcome from a prospective study
I Eser1, N Yologlu1, C Baydemir2
1Division of Pediatric Allergy and Immunology, Kocaeli University, 41380 Umuttepe, Kocaeli, Turkey.
Background:
There are few studies in children on the natural course of chronic spontaneous urticaria (CSU) because of its relative infrequency in childhood.
Objective:
To estimate the rate of remission and evaluate the prognostic factors in children with CSU.
Method:
A total of 52 children with CSU were prospectively followed over a period of three years.
Results:
The remission rates at 12 months and 36 months were 32.7% and 48.1%. The mean duration of disease at the first visit in the non-remission group was higher than in the remission group at the end of the study (P=0.016). The remission rate of the patients who had been treated by standard dose antihistamine was higher than that of the patients who had been treated with the high-dose antihistamine and combination medications (P=0.004, P<0.001). The treatment steps were independent prognostic factors for remission by logistic regression analysis.
Conclusion:
Our study indicates that urticaria controlled by a standard dose of antihistamine can predict a good prognosis independently from disease duration at first visit.
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