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Updated: Mar 17, 2026

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
Published on: April 23, 2017
The influence of cartilage surface topography on fluid flow in the intra-articular gap
Yabin Wu1, Stephen J Ferguson1
1a Institute for Biomechanics , ETH Zurich , Zurich , Switzerland.
Abstract:
Self-lubrication of a diarthrodial joint is largely attributed to interstitial fluid pressurisation. However, the retention of synovial fluid within the intra-articular gap may also contribute to lubrication. Fluid flow in the intra-articular gap between two micro-rough cartilage surfaces was simulated with a three-dimensional numerical model. Representative surface roughness parameters were incorporated and their relative influence on gap flow resistance was quantified. Resistance changes with decreasing gap height were explored. Cartilage surface micro-topography improves the retention of viscous synovial fluid in the gap, through increased resistance to tangential flow. Local asperity contact greatly increases resistance through tortuosity of the flow path.
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