Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor neuropathy with multifocal conduction blocks.

P Van den Bergh1, E L Logigian, J J Kelly

  • 1Department of Neurology, Tufts University School of Medicine, New England Medical Center Hospitals, Boston, MA.

Muscle & Nerve
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biofilm assemblage and activity on plastic in urban streams at a continental scale: Site characteristics are more important than substrate type.

The Science of the total environment·2022
Same author

Single-longitudinal-mode pumped pulsed-dye amplifier for high-resolution laser spectroscopy.

The Review of scientific instruments·2020
Same author

Late-onset Pompe disease (LOPD) in Belgium: clinical characteristics and outcome measures.

Orphanet journal of rare diseases·2020
Same author

Double deletion of Panx1 and Panx3 affects skin and bone but not hearing.

Journal of molecular medicine (Berlin, Germany)·2019
Same author

Compliance with international guidelines for chronic inflammatory neuropathies.

European journal of neurology·2018
Same author

Microplastic in riverine fish is connected to species traits.

Scientific reports·2018

This study details a rare pure motor demyelinating polyneuropathy. The patient showed improvement with immunosuppressive therapy and plasma exchange, suggesting an inflammatory neuropathy variant.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Chronic acquired demyelinating polyneuropathies represent a spectrum of neurological disorders.
  • Pure motor involvement without sensory deficits is less common in demyelinating neuropathies.
  • Understanding variants of inflammatory polyneuropathies is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To describe a unique case of chronic, pure motor, demyelinating polyneuropathy.
  • To investigate the electrodiagnostic and histopathological findings.
  • To evaluate the response to immunosuppressive treatments.

Main Methods:

  • Detailed clinical assessment of a patient with progressive motor weakness.
  • Electrophysiological studies including nerve conduction studies to identify conduction blocks.

Related Experiment Videos

  • Sural nerve biopsy for histopathological examination.

    • Main Results:

    • The patient presented with a chronic, symmetric, monophasic, acquired, pure motor demyelinating polyneuropathy.
    • Electrodiagnostic studies revealed multifocal conduction blocks in motor nerves at unusual sites.
    • Sural nerve biopsy results were unremarkable, showing no significant pathology.

    Conclusions:

    • The described polyneuropathy is an unusual variant, possibly of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
    • The patient's positive response to immunosuppressive therapy and plasma exchange supports an immune-mediated etiology.
    • This case highlights the heterogeneity of demyelinating neuropathies and the importance of considering atypical presentations.