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Updated: Mar 17, 2026
Corticospinal Excitability Modulation During Action Observation
Published on: December 31, 2013
Event related desynchronisation predicts functional propriospinal myoclonus
A M Meppelink1,2, S Little1, A Oswal1
1Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL), Institute of Neurology, London, United Kingdom.
Objective:
Recent diagnostic criteria for functional movement disorders have proposed a "laboratory supported" level of diagnostic certainty where the clinical diagnosis is supported by a positive test. For functional myoclonus the Bereitschaftspotential (BP) is generally accepted as a positive laboratory test. We hypothesised that a different EEG measure, event-related desynchronisation (ERD), might be more effective.
Methods:
We analysed 20 patients with functional propriospinal myoclonus (fPSM) and 9 controls with organic myoclonus and performed back-averaging for BPs plus time-frequency decomposition to assess ERD and calculated sensitivity and specificity for both techniques.
Results:
The BP was present in only 25% of patients with fPSM while the majority showed a significant ERD (mean 38 Hz; sensitivity 65%). ERD was significant at the group level (p < 0.001), but not the BP (p > 0.05). Both BP and ERD were absent in our control group.
Conclusion:
ERD in high-beta may be a useful new test for positive diagnosis of functional myoclonus.
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