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Live Imaging of the Mitochondrial Glutathione Redox State in Primary Neurons using a Ratiometric Indicator
Published on: October 20, 2021
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Redox-based therapeutics in neurodegenerative disease
G J McBean1, M G López2, F K Wallner3
1School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland.
British Journal of Pharmacology
|August 2, 2016
Summary
This review explores therapeutic strategies targeting redox homeostasis to combat neurodegenerative diseases like Alzheimer's and Parkinson's by reducing oxidative damage. Future research focuses on enhancing antioxidant capacity and mitigating cellular dysfunction.
Area of Science:
- Redox biology and oxidative stress in neurodegenerative diseases.
Background:
- Neurodegenerative diseases such as Alzheimer's, Parkinson's, ALS, and MS are characterized by disrupted thiol redox homeostasis.
- Oxidative damage is a significant factor contributing to the progression of these debilitating conditions.
Purpose of the Study:
- To review recent advancements in therapeutic agents targeting redox homeostasis in neurodegenerative diseases.
- To discuss experimental strategies for preventing or minimizing oxidative damage.
Main Methods:
- Focus on Nrf2 pathway activation to increase antioxidant capacity.
- Development of NADPH oxidase inhibitors for clinical application.
- Strategies to reduce nitrosative stress and mitochondrial dysfunction are evaluated.
Main Results:
- Several therapeutic avenues show promise in preclinical studies.
- Shortcomings of current compounds hindering clinical progression are identified.
Conclusions:
- Targeting redox homeostasis offers a promising strategy for treating neurodegenerative diseases.
- Future research should focus on overcoming current limitations and advancing effective therapies.
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