Related Experiment Video

Updated: Mar 17, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.7K

Correlations between Plasma Levels of Anionic Uremic Toxins and Clinical Parameters in Hemodialysis Patients

Yuichi Ichimura1, Hiroyuki Takamatsu, Hideki Ideuchi

  • 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|August 2, 2016
PubMed

Insights

Plasma indoxyl sulfate (IS) levels in chronic kidney disease patients correlate significantly with serum creatinine (Scr). This finding suggests IS levels can be predicted using Scr, aiding in managing uremic toxin accumulation.

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Pharmacokinetics

Background:

  • Uremic toxins (UTs) accumulate in chronic kidney disease (CKD), impacting physiological functions and drug efficacy.
  • Accurate measurement of plasma UT levels is crucial for managing CKD patients.
  • The relationship between UTs and clinical biomarkers requires further elucidation.

Purpose of the Study:

  • To assess correlations among plasma indoxyl sulfate (IS), indoleacetic acid (IA), and 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) levels.
  • To evaluate the relationship between plasma UT levels and clinical parameters (serum creatinine [Scr], blood urea nitrogen, estimated glomerular filtration rate [eGFR]).
  • To specifically investigate the correlation between plasma IS and clinical parameters in hemodialysis patients.

Main Methods:

  • Plasma samples were collected from 20 hemodialysis patients before and after treatment.
  • Levels of IS, IA, and CMPF were measured.
  • Correlations between UT levels and clinical parameters (Scr, eGFR) were analyzed.

Main Results:

  • No significant correlations were found among plasma levels of IS, IA, and CMPF.
  • A significant positive correlation was observed between plasma IS and Scr, strengthening post-hemodialysis (r=0.744, p<0.001).
  • Plasma IS showed a significant negative correlation with eGFR (r=-0.558, p=0.011), while IA and CMPF did not correlate with these parameters.

Conclusions:

  • Plasma IS levels can be predicted using serum creatinine (Scr) in CKD patients.
  • The strong correlation between IS and Scr suggests Scr as a potential surrogate marker for IS.
  • Further research is needed to clarify the underlying mechanisms of the IS-Scr relationship.

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.4K
A Murine Model of Hemodialysis Access-Related Hand Dysfunction08:39

A Murine Model of Hemodialysis Access-Related Hand Dysfunction

Published on: May 31, 2022

2.1K

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
581
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
880
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1.6K
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
293
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
1.3K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
452