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Multi-functional lectin-like transcript-1: A new player in human immune regulation

Alba Llibre1, Paul Klenerman2, Christian B Willberg2

  • 1Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.

Immunology Letters
|August 2, 2016
PubMed

Lectins and C-type lectins are a heterogeneous group of proteins with a diverse range of functions. Two C-type lectins, found in the Natural Killer gene Complex (NKC), Lectin-like transcript 1 (LLT1) and CD161, have recently gained interest from a broad range of immunological and non-immunological fields. LLT1 in particular has a diverse functional repertoire, from NK cell and B cell regulation to bone metabolism. This review seeks to bring together nearly two decades of research on these receptors and describe their importance in the immune system.

Keywords:
C-type lectin-like receptorsCarbohydrate recognition domainLectin-like transcript 1Natural killer gene complexOsteoclast inhibitory lectin

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