Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cohesins

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...

Cohesins

Cohesins

Attachment of Sister Chromatids

Attachment of Sister Chromatids

As cells progress into mitosis, the nuclear envelope breaks down, and the condensed chromosomes are exposed to the array of bipolar microtubules of the mitotic spindle. The kinetochore, a large, disc-shaped protein complex, is present at the centromere region of the sister chromatids and acts as a binding site for the microtubules. Usually, the plus-end of a single microtubule is embedded within the kinetochore. However, some kinetochores first establish lateral contact with the side-wall...

Attachment of Sister Chromatids

Attachment of Sister Chromatids

Condensins

Condensins

Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...

Condensins

Condensins

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

LSD1-based dual-target inhibitors as emerging anticancer agents: pharmacological perspectives and SAR exploration.

Future medicinal chemistry·2026

Same author

Single-cell mapping of regulatory DNA-protein interactions.

Cell·2026

Same author

SARS-CoV-2 Nsp13 helicase resolves G-quadruplexes and is inhibited by G4 ligands or an antiviral regulator: Implications for G4 anti-coronavirus therapies.

The Journal of biological chemistry·2026

Same author

Rare genetic diseases associated with G-quadruplex-induced replication stress.

Communications biology·2026

Same author

Effect of Nanobubbles on Ultrafiltration Membrane Performance and Properties of Model Cheese Whey.

Foods (Basel, Switzerland)·2025

Same author

Same mutation, different fates: The Yin-Yang of BRAF-driven therapeutic responses in melanoma and colorectal cancer.

Biochimica et biophysica acta. Reviews on cancer·2025

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

Chromatin Isolation by RNA Purification ChIRP

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

A Long Noncoding RNA Regulates Sister Chromatid Cohesion.

Francesco P Marchese¹, Elena Grossi¹, Oskar Marín-Béjar¹

¹Center for Applied Medical Research (CIMA), Department of Gene Therapy and Regulation of Gene Expression, University of Navarra, 55 Pio XII Avenue, 31008 Pamplona, Spain; Institute of Health Research of Navarra (IdiSNA), 31008 Pamplona, Spain.

|August 2, 2016

Summary

A novel long noncoding RNA, CONCR, is essential for cell division by regulating DNA replication and sister chromatid cohesion through interaction with the DDX11 protein.

More Related Videos

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Related Experiment Videos

Last Updated: Mar 17, 2026

Chromatin Isolation by RNA Purification ChIRP

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

Molecular Biology
Genetics
Cell Biology

Background:

Long noncoding RNAs (lncRNAs) play diverse roles in cellular processes.
The function of many lncRNAs, including their role in cell division, remains poorly understood.

Purpose of the Study:

To characterize a novel human lncRNA, CONCR (cohesion regulator noncoding RNA).
To investigate the role of CONCR in cell cycle regulation, DNA replication, and sister chromatid cohesion.

Main Methods:

Transcriptional analysis of CONCR expression.
Depletion studies using RNA interference to assess CONCR function.
Co-immunoprecipitation and enzymatic activity assays to study CONCR-DDX11 interaction.

Main Results:

CONCR is upregulated in multiple cancer types and regulated by MYC.
CONCR is crucial for cell-cycle progression, DNA replication, and sister chromatid cohesion.
CONCR interacts with and modulates the enzymatic activity of DDX11, a key protein in DNA replication and cohesion.

Conclusions:

CONCR is a novel lncRNA with a critical role in establishing sister chromatid cohesion.
CONCR regulates DDX11 activity, highlighting a direct lncRNA involvement in cell division mechanics.