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Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the
1Laboratori de Neuropsicofarmacología i Programa Sant Pau-CITRAN, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de Sant Pau (Medical School, U.A.B.), Barcelona, Spain.
Abstract:
The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.