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Published on: March 18, 2019
Ofatumumab treatment in lupus nephritis patients
Malena Loberg Haarhaus1, Elisabet Svenungsson1, Iva Gunnarsson1
1Department of Medicine, Rheumatology Unit , Karolinska Institute , Stockholm , Sweden.
Abstract:
Rituximab is frequently used in systemic lupus erythematosus; however, side effects such as infusion-related reactions limit its use. In this case report, we describe, for the first time, treatment with ofatumumab in four patients with lupus nephritis. The treatment was well tolerated in three of the patients, and a reduction of proteinuria was seen in all cases. This emphasizes the importance of alternative B-cell-depleting therapies in patients with an initial good response to rituximab, but who develop side effects.
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