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Updated: Mar 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Granulomatous interstitial nephritis and Crohn's disease
Sjoerd A M E G Timmermans1, Maarten H L Christiaans1, Myrurgia A Abdul-Hamid2
1Department of Internal Medicine, Division of Nephrology and Clinical Immunology , Maastricht University Medical Centre, Maastricht.
Abstract:
Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatment, renal function either improved or stabilized in both patients. In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents.
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