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Successful Control of Massive Bleeding in a Child with Burkitt's Lymphoma via a Biosimilar Recombinant Activated

Kourosh Goudarzi Pour1, Fatemeh Malek1, Peyman Eshghi1

  • 1Paediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran 15514-15468, Iran.

Case Reports in Hematology
|August 2, 2016
PubMed

Insights

A pediatric case of Burkitt

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Pharmacology

Background:

  • Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma.
  • Chemotherapy for Burkitt's lymphoma can lead to severe complications like gastrointestinal hemorrhage.
  • Thrombocytopenia and coagulopathy are common, life-threatening side effects of chemotherapy.

Purpose of the Study:

  • To report a case of massive gastrointestinal hemorrhage in a pediatric patient with Burkitt's lymphoma post-chemotherapy.
  • To evaluate the efficacy of a biosimilar recombinant activated human factor VII in managing refractory bleeding.
  • To highlight a potential treatment option for severe bleeding complications in pediatric oncology.

Main Methods:

  • A case report of a 4-year-old girl with Burkitt's lymphoma.
  • Management of massive gastrointestinal hemorrhage and persistent thrombocytopenia after chemotherapy.
  • Administration of a single dose of biosimilar recombinant activated human factor VII (AryoSeven).

Main Results:

  • The patient experienced massive gastrointestinal hemorrhage 3 days post-chemotherapy.
  • Standard correction of coagulopathy and thrombocytopenia were ineffective.
  • A single dose of AryoSeven successfully controlled the life-threatening bleeding.

Conclusions:

  • Biosimilar recombinant activated human factor VII can be an effective treatment for life-threatening gastrointestinal hemorrhage in pediatric Burkitt's lymphoma patients.
  • This case suggests a potential role for AryoSeven in managing refractory bleeding associated with chemotherapy-induced coagulopathy.
  • Further investigation into the use of recombinant activated human factor VII in pediatric oncology emergencies is warranted.

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