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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Bacterial Flora of the Large Intestine01:29

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Assessment of the Rectum and Anus01:25

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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Updated: Mar 17, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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Intestinal microbiota and chronic constipation.

Ying Zhao1, Yan-Bo Yu2

  • 1Department of Geriatrics, Jinan Military General Hospital, Jinan, 250031 People's Republic of China.

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|August 2, 2016
PubMed
Summary
This summary is machine-generated.

Altered intestinal microbiota may play a role in chronic constipation. Understanding gut microbiota function offers new therapeutic targets for this common gastrointestinal disorder.

Keywords:
Chronic constipationGut motilityIntestinal microbiotaProbiotics

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Human Health

Background:

  • Chronic constipation is a common gastrointestinal disorder with unclear causes.
  • Studies show differences in gut microbiota between constipated individuals and healthy people.
  • Intestinal microbiota alterations are increasingly linked to constipation and its symptoms.

Purpose of the Study:

  • To review current evidence on the role of intestinal microbiota in chronic constipation.
  • To explore novel mechanisms of microbiota-gut function interactions.
  • To identify potential new therapeutic strategies for constipation.

Main Methods:

  • Literature review of existing studies on intestinal microbiota and chronic constipation.
  • Analysis of research on gut microbiota composition and function.
  • Synthesis of evidence linking microbiota changes to constipation pathogenesis.

Main Results:

  • Significant differences exist in the gut microbiota of constipated patients compared to healthy controls.
  • Intestinal microbiota performs vital functions including nutrient absorption and immune support.
  • Evidence suggests microbiota dysbiosis contributes to the development of constipation.

Conclusions:

  • The intestinal microbiota is implicated in the pathogenesis of chronic constipation.
  • Understanding microbiota-gut interactions is crucial for developing new treatments.
  • Targeting the gut microbiota may offer novel therapeutic avenues for constipation management.