Infantile Colic Is Associated With Low-grade Systemic Inflammation.
Anna Pärtty1, Marko Kalliomäki, Seppo Salminen
1*Department of Pediatrics and Department of Pediatric and Adolescent Medicine, University of Turku and Turku University Hospital †Functional Foods Forum, University of Turku, Turku, Finland.
Journal of Pediatric Gastroenterology and Nutrition
|August 2, 2016
Summary
Infant colic is linked to gut dysbiosis and low-grade inflammation. Specific gut bacteria may possess anti-inflammatory properties that could help manage colic symptoms.
Area of Science:
- Microbiology
- Immunology
- Pediatrics
Background:
- Infant colic is often associated with gut microbiota alterations.
- Dysbiosis during development can lead to lasting immunological and metabolic changes, especially with inflammation.
- Probiotics have shown success in treating colic, suggesting a role for gut bacteria.
Purpose of the Study:
- To investigate if infants with colic exhibit low-grade systemic inflammation.
- To explore the relationship between gut microbiota composition and immunological biomarkers in colicky infants.
Main Methods:
- Serum immunological biomarkers (cytokines, chemokines, intestinal permeability markers) were measured in 28 infants with colic and 12 healthy controls.
- Fecal microbiota composition was analyzed and correlated with serum immunological markers.
Main Results:
- Infants with colic showed elevated serum levels of IL-8, MCP-1, and MIP-1β compared to controls.
- Fecal levels of Clostridium leptum and C. coccoides group correlated negatively with pro-inflammatory markers.
- Bifidobacterium breve levels showed a positive correlation with chemokine (C-X-C motif) ligand 16.
Conclusions:
- Colic in infants is associated with gut dysbiosis and low-grade systemic inflammation.
- Certain bacterial species, beyond traditional probiotics, may have anti-inflammatory effects beneficial for colic management.
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