Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.2K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.2K
Understanding Sleep01:11

Understanding Sleep

1.8K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.8K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.2K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

5.8K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internet use 101 in college: Do undergraduates want to learn healthier internet use?

Public health in practice (Oxford, England)·2023
Same author

Daytime Sleepiness Is Associated with Lower Cognitive Scores: The Look AHEAD Study.

JAR life·2023
Same author

RESEARCH OF FOREIGN BODIES SOFT TISSUE GUNSHOT ORIGIN.

Georgian medical news·2020
Same author

Sleep-obesity relation: underlying mechanisms and consequences for treatment.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Aberrant development of intrinsic brain activity in a rat model of caregiver maltreatment of offspring.

Translational psychiatry·2017
Same author

A sipometer for measuring motivation to consume and reward value of foods and beverages in humans: Description and proof of principle.

Physiology & behavior·2017

Related Experiment Video

Updated: Mar 17, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

Sleep and meal-time misalignment alters functional connectivity: a pilot resting-state study.

Y N Yoncheva1, F X Castellanos1,2, T Pizinger3

  • 1The Child Study Center at NYU Langone Medical Center, New York, NY, USA.

International Journal of Obesity (2005)
|August 2, 2016
PubMed
Summary

Delayed sleep and meal times disrupt brain connectivity, impacting food reward and interoception. This study explored how misaligned sleep and eating schedules affect brain function, independent of sleep duration.

More Related Videos

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
10:56

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Published on: August 2, 2017

10.6K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.7K

Related Experiment Videos

Last Updated: Mar 17, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K
Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
10:56

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice

Published on: August 2, 2017

10.6K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.7K

Area of Science:

  • Neuroscience
  • Metabolic Health
  • Chronobiology

Background:

  • Delayed sleep and meal times are linked to metabolic dysregulation and obesity.
  • The impact of misaligned sleep and eating schedules on brain function, particularly food reward and interoception, remains unclear.
  • Understanding these effects independently of sleep duration is crucial.

Purpose of the Study:

  • To experimentally investigate the independent and combined effects of delayed sleep and meal times on resting-state functional connectivity (RSFC).
  • To examine how these timing shifts influence brain regions associated with food reward and interoception.
  • To assess the feasibility of studying sleep-meal time misalignment separate from sleep duration.

Main Methods:

  • A randomized, in-patient crossover study design.
  • Experimental manipulation of sleep and meal times while maintaining constant sleep duration (approx. 7 hours).
  • Resting-state functional magnetic resonance imaging (rs-fMRI) to measure RSFC in four conditions: normal sleep/normal meal, late sleep/normal meal, normal sleep/late meal, and late sleep/late meal.

Main Results:

  • Significant, regionally specific effects on RSFC were observed across conditions (P<0.05, whole-brain corrected).
  • The amygdala showed the strongest effects, with increased RSFC during late versus normal mealtimes, akin to skipping breakfast.
  • Main effects of sleep timing and interactions between sleep and meal timing on RSFC were detected.

Conclusions:

  • The study demonstrates the feasibility of examining the impact of sleep-meal time misalignment on brain connectivity, independent of total sleep duration.
  • Findings suggest that altered timing of sleep and meals significantly affects neural pathways involved in food reward and interoception.
  • These results provide a foundation for further research into the neurobiological mechanisms underlying metabolic dysregulation due to circadian misalignment.