Related Experiment Video
Updated: Mar 17, 2026
05:42
The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
40.3K
Suicide behavior as a quantitative trait and its genetic background.
Joanna Pawlak1, Monika Dmitrzak-Weglarz1, Monika Wilkosc2
1Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland.
Journal of Affective Disorders
|August 2, 2016
Summary
Genetic variations in several key genes are linked to suicidal behavior risk. This study identified specific gene variants contributing to suicidal predisposition in affective patients.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The genetic underpinnings of suicidal predisposition remain unclear.
- Previous research suggests associations between specific gene polymorphisms and suicidal behavior.
Purpose of the Study:
- To investigate the association between genetic polymorphisms in candidate genes and suicidal behavior.
- To explore the interactions of these genes in contributing to suicidal risk.
Main Methods:
- Analysis of 35 single nucleotide polymorphisms (SNPs) in 10 candidate genes, including SLC6A4 and ACP1.
- Examined 825 patients with affective disorders and a precisely described suicidal phenotype.
Main Results:
- Confirmed the involvement of variants in TPH1, TPH2, 5HT2A, CRHR1, and ACP1 genes in suicidal behavior risk.
- Identified polymorphisms in various signaling pathways associated with the pathogenesis of suicidal behavior.
Conclusions:
- Genetic factors, specifically polymorphisms in multiple signaling pathways, play a role in suicidal behavior.
- Non-genetic factors also contribute significantly to the risk of suicidal attempts.
Related Concept Videos
01:23Behavioral Genetics and Its Designs
1.2K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.2K
01:28Human Genetics
1.8K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
01:18Polygenic Traits
11.3K
11.3K
01:18Polygenic Traits
70.1K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
70.1K
01:06Heritability
804
Heritability is a statistical concept that measures the degree to which genetic differences among individuals contribute to trait variations within a population. It is a fundamental idea in genetics, often prone to misinterpretation. Heritability is expressed as a percentage, reflecting the proportion of variation in a specific trait across a population that can be linked to genetic differences. However, it's important to understand that heritability does not determine how "genetic"...
804
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
94
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
94