Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Gene Therapy00:59

Gene Therapy

27.9K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging 2D Materials and Their Hybrid Nanostructures for Label-Free Optical Biosensing: Recent Progress and Outlook.

Advanced functional materials·2026
Same author

Retraction Note: A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA).

Journal of orthopaedic surgery and research·2026
Same author

Next-generation health monitoring: The role of nanomaterials in 3D-printed wearable devices.

Materials today (Kidlington, England)·2026
Same author

An improved fluorescent indicator for monitoring intracellular redox potential.

Redox biology·2026
Same author

Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma.

Cell host & microbe·2026
Same author

Differential clinical impact of HLA-DPA1~DPB1 linkage mismatches in 14/14-matched unrelated donor HSCT: a multicenter retrospective study from CMDP revealing age- and disease-specific risk patterns.

Bone marrow transplantation·2026

Related Experiment Video

Updated: Mar 17, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

16.8K

Recent progress in nanomaterials for gene delivery applications.

Erhan Keles1, Yang Song2, Dan Du2

  • 1Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA 99164, USA.

Biomaterials Science
|August 3, 2016
PubMed
Summary

Nonviral nanomaterials show promise for gene therapy, offering advantages over viral vectors. Further research is needed to address toxicity and efficiency concerns for clinical applications.

More Related Videos

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

13.4K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.7K

Related Experiment Videos

Last Updated: Mar 17, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

16.8K
Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
08:02

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

13.4K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

25.7K

Area of Science:

  • Nanomedicine
  • Materials Science
  • Biotechnology

Background:

  • Nanotechnology-based gene delivery utilizes nanomaterials for targeted delivery of genetic material.
  • Gene therapy holds potential for treating diseases like cancer and neurological disorders.
  • Current clinical use is limited by safety and efficacy concerns, with no FDA-approved systems.

Purpose of the Study:

  • To review nonviral gene delivery systems based on nanomaterials.
  • To discuss recent advances in nanomaterials for gene therapy applications.
  • To highlight challenges and concerns regarding in vivo use.

Main Methods:

  • Focuses on nonviral gene delivery systems (lipids, polymers, graphene, inorganic nanoparticles).
  • Briefly describes nanomaterial synthesis from a materials science perspective.
  • Reviews recent advances and discusses challenges.

Main Results:

  • Nonviral vectors exhibit lower immunogenicity and higher loading capacity than viral vectors.
  • Various nanomaterials are being explored for gene delivery applications.
  • Key challenges include in vivo toxicity and low transfection efficiency.

Conclusions:

  • Nonviral nanomaterial-based gene delivery systems offer significant therapeutic potential.
  • Addressing toxicity and efficiency is crucial for clinical translation.
  • Continued research in nanomaterial design and application is essential for advancing gene therapy.