Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delivery of mRNA Therapeutics Beyond Infectious Diseases: Design Innovations and Applications in Oncology, Cardiovascular, and Rare Genetic Diseases.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Investigating the In Vitro Immunomodulatory Potential of Microparticulate β-L-Adenosine in Particulate Vaccine Candidates.

Vaccines·2026
Same author

Phytochemical Profiling and Computational Docking Studies Revealing the Potential Anticancer and Antioxidant Properties of <i>Heliotropium indicum</i> L.

Scientifica·2026
Same author

Pre-pandemic lifestyle patterns and mental health outcomes among people reporting post-acute sequelae of COVID-19: evidence from a Slovenian population-based sample.

BMC public health·2025
Same author

Absolute and Relative Effectiveness of Cell- and Egg-based Quadrivalent Inactivated Influenza Vaccine Products from 2014-2015 to 2018-2019 seasons, U.S. Flu VE Network.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

The Current Practice of Laparoscopically Assisted Anorectoplasty for Male Patients - An International Pediatric Endosurgery Group Survey.

Journal of pediatric surgery·2025

Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K

Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis.

Lena Perger1,2,3, Dhriti Mukhopadhyay1,4, Luka Komidar5

  • 1a Texas A&M College of Medicine , Temple , TX , USA .

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|August 3, 2016
PubMed
Summary

Maternal pre-eclampsia (PE) is linked to necrotizing enterocolitis (NEC) in newborns, particularly those with intrauterine growth restriction (IUGR). Fetal hypoxia from PE may increase NEC risk in affected infants.

Keywords:
Necrotizing enterocolitisnewbornpre-eclampsiasmall for gestational age

More Related Videos

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.9K

Related Experiment Videos

Last Updated: Mar 17, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.5K
Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation
09:02

Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation

Published on: February 15, 2018

20.0K
Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model
06:51

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

1.9K

Area of Science:

  • Neonatal Medicine
  • Perinatal Research
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia (PE) and necrotizing enterocolitis (NEC) share similar pro-inflammatory pathways.
  • Understanding the relationship between maternal PE and infant NEC is crucial for neonatal outcomes.

Purpose of the Study:

  • To investigate if maternal pre-eclampsia (PE) is an independent risk factor for the development of necrotizing enterocolitis (NEC) in live-born infants.
  • To analyze the association between PE and NEC, considering factors like gestational age, birth weight, and intrauterine growth restriction (IUGR).

Main Methods:

  • Retrospective analysis of live births between 2008-2011 at a tertiary care center.
  • Comparison of infant and maternal characteristics between babies born to mothers with and without PE.
  • Statistical analysis including Mann-Whitney U, Pearson's chi-squared, binary logistic regression, and relative risks.

Main Results:

  • The incidence of NEC was significantly higher in infants of mothers with PE (4.6%) compared to those without (1.5%).
  • This association lost statistical significance after controlling for gestational age and birth weight.
  • However, PE remained a significant risk factor for NEC in infants with intrauterine growth restriction (IUGR), with a 13.6% incidence in the PE group versus 1.5% in the non-PE group.

Conclusions:

  • Maternal pre-eclampsia (PE) is an independent risk factor for necrotizing enterocolitis (NEC) in specific infant subgroups, particularly those with intrauterine growth restriction (IUGR).
  • Fetal hypoxia, stemming from abnormal placentation in PE, may lead to restricted growth and predispose newborns to NEC.
  • This highlights the importance of monitoring infants with PE and IUGR for potential NEC development.