Nitric Oxide-Releasing Biomaterials for Biomedical Applications

Area of Science:

• Biomaterials Science
• Biomedical Engineering
• Drug Delivery Systems

Background:

• Nitric oxide (NO) is a crucial signaling molecule in physiological and pathological processes.
• Existing low molecular weight NO donors face challenges like burst release and poor targeting.
• Biomaterial-based carriers present a strategy for controlled and sustained NO delivery.

Purpose of the Study:

• To review the progress of NO-releasing biomaterials.
• To highlight the biomedical applications of these advanced NO delivery systems.
• To inspire new perspectives in biomaterial-based NO delivery.

Main Methods:

• Fabrication of NO-releasing biomaterials including nanoparticles, hydrogels, and coatings.
• Attachment and loading of NO-donor prodrugs onto diverse biomaterials.
• Utilizing physical, chemical, or supramolecular techniques for NO integration.

Main Results:

• NO-releasing biomaterials demonstrate potential in cardiovascular applications by mimicking endothelium.
• These materials show promise as wound dressings for accelerated tissue regeneration.
• Localized, sustained NO delivery to tumors via biomaterials can achieve potent tumoricidal effects.

Conclusions:

• Biomaterial-based NO delivery systems offer significant advantages over traditional NO donors.
• These systems have broad biomedical applications, including regenerative medicine and cancer therapy.
• Further research into biomaterial-based NO delivery systems is warranted for clinical translation.