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Contact Lens-induced Limbal Stem Cell Deficiency
Jennifer Rossen1, Alec Amram1, Behrad Milani1
1Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
The Ocular Surface
|August 3, 2016
Summary
Contact lens wear can cause limbal stem cell deficiency (LSCD), a condition affecting corneal health. This review explores the epidemiology, diagnosis, and treatment of CL-induced LSCD.
Area of Science:
- Ophthalmology
- Corneal Science
- Stem Cell Biology
Background:
- Limbal stem cell deficiency (LSCD) impairs corneal epithelium regeneration.
- Corneal conjunctivalization is a clinical hallmark of LSCD.
- Contact lens (CL) wear is an underrecognized cause of LSCD.
Purpose of the Study:
- To critically review contact lens wear as a cause of limbal stem cell disease.
- To consolidate current knowledge on CL-induced LSCD.
Main Methods:
- Comprehensive literature search for original articles on CL-induced LSCD.
- Review focused on epidemiology, diagnostics, pathogenesis, differential diagnosis, and treatment.
Main Results:
- Contact lens wear presents a significant risk factor for developing LSCD.
- The review synthesizes data on the multifaceted aspects of CL-induced LSCD.
Conclusions:
- Contact lens wear necessitates careful consideration in the differential diagnosis of LSCD.
- Further research and clinical awareness are crucial for managing CL-related ocular surface disease.
