Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

Contact Lens-induced Limbal Stem Cell Deficiency.

Jennifer Rossen¹, Alec Amram¹, Behrad Milani¹

¹Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The Ocular Surface

|August 3, 2016

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical and molecular response to vorasidenib in post-transplant patient with IDH2-mutant intrahepatic cholangiocarcinoma.

The oncologist·2026

Same author

Novel Visible-Light Curable Hydrogel for Closure of Sclerotomy Wounds in Pars Plana Vitrectomy.

Journal of vitreoretinal diseases·2026

Same author

Serum inflammatory biomarkers in ocular pemphigoid closely resemble that of dry eye disease: A cross-sectional study.

The ocular surface·2026

Same author

Measuring historical variant reclassification in inherited retinal disease and its impact on clinical genetic testing.

Ophthalmic genetics·2025

Same author

Microfluidic Determination of Cell-Derived ATP and Single Cell Pressure Mapping Confirms Benefits of Normoglycemic Stored Red Blood Cells.

ACS measurement science au·2025

Same author

Performance of DeepSeek, Qwen 2.5 MAX, and ChatGPT Assisting in Diagnosis of Corneal Eye Diseases, Glaucoma, and Neuro-Ophthalmology Diseases Based on Clinical Case Reports.

medRxiv : the preprint server for health sciences·2025

Contact lens wear can cause limbal stem cell deficiency (LSCD), a condition affecting corneal health. This review explores the epidemiology, diagnosis, and treatment of CL-induced LSCD.

Area of Science:

Ophthalmology
Corneal Science
Stem Cell Biology

Background:

Limbal stem cell deficiency (LSCD) impairs corneal epithelium regeneration.
Corneal conjunctivalization is a clinical hallmark of LSCD.
Contact lens (CL) wear is an underrecognized cause of LSCD.

Purpose of the Study:

To critically review contact lens wear as a cause of limbal stem cell disease.
To consolidate current knowledge on CL-induced LSCD.

Main Methods:

Comprehensive literature search for original articles on CL-induced LSCD.
Review focused on epidemiology, diagnostics, pathogenesis, differential diagnosis, and treatment.

Main Results:

Contact lens wear presents a significant risk factor for developing LSCD.

Keywords:

contact lens corneal conjunctivalization limbal stem cell deficiency limbal stem cells

More Related Videos

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

Related Experiment Videos

Last Updated: Mar 17, 2026

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

Published on: November 17, 2016

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research

Published on: October 27, 2023

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration

Published on: August 4, 2023

The review synthesizes data on the multifaceted aspects of CL-induced LSCD.

Conclusions:

Contact lens wear necessitates careful consideration in the differential diagnosis of LSCD.
Further research and clinical awareness are crucial for managing CL-related ocular surface disease.