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Regulation of Angiogenesis and Blood Supply

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

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Related Experiment Video

Updated: Mar 17, 2026

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Guest Editorial: Vascularization in Tissue Engineering

Laxminarayanan Krishnan¹

¹Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology; 315 Ferst Dr. NW, Atlanta, GA 30332.

Critical Reviews in Biomedical Engineering

|August 3, 2016

Summary

No abstract available in PubMed .

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