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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Association between Atrial Fibrillation and Three-Year Mortality in Nondiabetic Patients with Acute First-Ever

Chun-Hsueh Chu1, Wei-Chieh Weng1, Feng-Chieh Su1

  • 1Department of Neurology, Chang-Gung Memorial Hospital, Keelung, Taiwan; Department of Medicine, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|August 3, 2016
PubMed

Insights

Atrial fibrillation (AF) increases 3-year mortality risk in nondiabetic patients after ischemic stroke. Early cardiac evaluation and treatment are crucial for managing stroke outcomes in these patients.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Diabetes mellitus (DM) is a known risk factor for atrial fibrillation (AF) and stroke mortality.
  • The impact of AF on long-term outcomes in ischemic stroke patients requires further clarification, especially independent of DM.
  • This study investigates AF's influence on 3-year outcomes in nondiabetic patients with acute first-ever ischemic stroke.

Purpose of the Study:

  • To determine the independent effect of atrial fibrillation (AF) on the 3-year outcomes of nondiabetic patients experiencing an acute first-ever ischemic stroke.
  • To assess the association between AF and mortality, functional status, and healthcare utilization in this specific patient cohort.
  • To provide evidence supporting targeted cardiac evaluation and management strategies for stroke patients with AF.

Main Methods:

  • A cohort of 574 nondiabetic patients with acute first-ever ischemic stroke was followed for 3 years.
  • Patients were categorized into two groups: those with and without diagnosed AF.
  • Clinical data, stroke risk factors, laboratory results, comorbidities, and 3-year outcomes were systematically recorded and analyzed.

Main Results:

  • Atrial fibrillation (AF) was diagnosed in 18.6% of the study population (107 patients).
  • Patients with AF were older and had a higher incidence of total anterior circulation syndrome.
  • AF was significantly associated with longer hospital stays, increased dependency post-discharge, and a 1.98-fold increased risk of 3-year all-cause mortality (P=.022).

Conclusions:

  • Atrial fibrillation (AF) is an independent predictor of increased 3-year mortality in nondiabetic patients following an acute ischemic stroke.
  • These findings underscore the critical need for thorough cardiac assessment and timely intervention in stroke patients diagnosed with AF.
  • Effective management of AF in stroke survivors is essential for improving long-term prognosis and reducing mortality.
Abstract

Keywords:
Atrial fibrillationdiabetes mellitusfirst-ever ischemic strokemortalitystroke outcome

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